The cross-agency offensive, which will target more than 1000 properties across the state during  spring, was announced by the Minister for Primary Industries Katrina Hodgkinson on Wednesday.

Wild dogs have become a "very significant problem" in parts of NSW, the minister said.  Livestock farmers bear the brunt of the burden.

"The loss to agricultural production is quite severe and that's why we want to have an all-out offensive," she said.

Ms Hodgkinson said it was hoped the statewide campaign, which has received $2.4 million in federal funding, would rectify the shortcomings of the "piecemeal approach" of previous operations, which had only succeeded in controlling populations in targeted areas.

"Obviously [the wild dogs] don't respect lines on maps," she said.

"By getting absolutely everybody on board, this is going to have the best possible impact."

A wild dog refers to any dog living in the wild, including feral dogs and dingoes, and is a declared pest under NSW law.

Marauding dog packs have become a particular menace for sheep farmers.

David Worsley, a sheep and cattle farmer from the Northern Tablelands, said baiting programs were "absolutely essential," as trapping and shooting were a less effective means of culling on large properties.

"I think I've only seen two wild dogs in my life for all the animals I've lost," he said.

Mr Worsley said he had lost as many as 300 sheep in one year to wild dog attacks, and often up to 14 sheep a night during a bad period.

"More often than not you have to actually euthanase the animals, rather than finding them dead," he said.

"You know before you get anywhere near [the sheep] you know it's going to have its back leg missing or its kidneys eaten.

"It's one of those absolutely gut wrenching things. Mentally it can be extremely hard on you."

Local Land Services will partner with 62 wild dog control groups to lay 240,000 baits across 765,00 hectares in the Central West, the greater Sydney area and the Riverina and Hunter regions.

Aerial baiting will be used to cover a further 4400 kilometres across more remote parts of NSW, including the vast West region where wild dogs problems have reappeared for the first time in generations.

"People who didn't know what a dog problem was are now faced with issues their fathers hadn't seen," Dr Peter Fleming, research scientist with the Department of Primary Industries, said.

Dr Fleming said the baiting program would likely be beneficial to native animals.

"The dogs are a predator of [native] wildlife," he said, "and there are indications that where you control dogs you get increases in things like brush-tail rock-wallabies."

A spokesperson for RSPCA NSW said wild pest management should be balanced with the "continuing need to improve current control methods or replace them with more humane and effective alternatives".

Ms Hodgkinson said the statewide offensive could become an annual operation if deemed a success by the Department of Primary Industries.