The 18-year-old Collingullie local was travelling along the Sturt Highway when she collided with a number of vehicles travelling in the opposite direction.

Paramedics treated the young woman at the scene, but she died en route to Wagga Wagga Base Hospital. No one else was injured in the crash.

Police say alcohol was not a factor in the incident.

"She only had her 18th birthday three weeks ago, so it's obviously very upsetting," Wagga Wagga police Acting Sergeant Cameron Ellis said.

A report is being prepared for the coroner.