The Wangaratta-based MP has called on the Victorian government to consider a more flexible region-by-region model for the next round of changes.

"There was, and in the future could be, the opportunity for regional communities to experience less restrictions and operate on a different time schedule to metropolitan Melbourne, especially given our comparatively, distinctly low case numbers," she said.

"The economic cost to regional areas has been high, especially on the back of drought and bushfires.

"Our communities need to understand now what the plan is for localised management of outbreaks over the coming months."

Premier Daniel Andrews has rejected the idea in the past, saying he wanted one rule for all of the state.

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Ms Maxwell took the issue to Victorian Parliament this week, asking what regard had been given to letting regional communities experience less restrictions and why it was rejected.

"The government continues to apply a statewide response to the virus, including for last week's directive that people avoid attending work to help relieve public transport pressure, when that is largely irrelevant to the way most northern Victorians travel to work," she said.

"Businesses and constituents in my electorate are contacting me to try and understand these restrictions.

"However, in rural areas the stringency of these restrictions is often seen as unnecessary given our minimal case numbers."