Dubbo is one of five major COVID-19 vaccination hubs for NSW that will begin to open from March 15.

The Dubbo hub will have 35 regional satellite sites across the district.

The vaccination hubs and satellite sites will initially focus on front line healthcare and border workers, and will eventually be followed by a wider roll-out of the vaccine to the general public through the GP network, the government reports.

The other four major hubs will be located at Newcastle, Wollongong, Wagga Wagga and Coffs Harbour hospitals.

The vaccine will be dispatched from the hubs to the satellite sites.

In the hub-and-spoke style model, the spokes linked to Dubbo are: Orange, Bathurst, Blayney, Oberon, Cowra, Grenfell, Eugowra, Canowindra, Mudgee, Gulgong, Dunedoo, Rylstone, Molong, Gilgandra, Gulargambone, Coonabarabran, Baradine, Coonamble, Coolah, Cobar, Nyngan, Warren, Trangie, Tottenham, Parkes, Forbes, Peak Hill, Tullamore, Trundle, Condobolin, Walgett, Collarenebri, Lightning Ridge, Brewarrina and Bourke.

Premier Gladys Berejiklian said it had been great to see the enormous enthusiasm from those receiving and giving the jabs.

"NSW is on track to achieve its goal of more than 35,000 vaccinations in the first three weeks with thousands of front line workers already receiving their first doses thanks to excellent work of our NSW Health staff in the three initial hubs," Ms Berejiklian said.

Deputy Premier John Barilaro said it was fantastic the roll-out of the vaccine would be expanded into regional NSW.

"Regional NSW has endured a myriad of impacts from COVID-19 and with the vaccine now on its way, we will have the confidence and assurance we need to live fully and remain open for business," Mr Barilaro said.

Health minister Brad Hazzard said rolling out vaccinations to front line staff in the regions was the next step to ensuring they were protected.